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To Help Build a New Class of Oligonucleotide Therapeutics

Job Location: Shanghai, Suzhou

Report to: Vice President, Clinical Development

Position Overview:
The Director/VP of Business Development will lead business development activities at Ractigen Therapeutics, focusing on driving value through strategic partnerships and collaborations. This role involves crafting compelling business cases, executing deals, managing alliances, and collaborating effectively with internal teams and the CEO to support company objectives.

Key Responsibilities:

1. Clinical Strategy & Study Design

• Preclinical to Clinical Translation: Evaluate preclinical in vitro ADME, PK/PD, and toxicology/toxicokinetic data to support robust clinical trial design.
• Study Design: Design, interpret, and report clinical PK/PD studies. Provide clinical pharmacology expertise for assigned projects to characterize pharmacological properties.
• Dose Rationale: Employ Modeling and Simulation (M&S) techniques to provide a scientific rationale for dose and regimen selection in clinical trials.

2. Execution & Data Analysis

• PK/PD Analysis: Execute non-compartmental and compartmental analysis; finalize PK study reports and integrated PK/PD reports.
• Vendor Management: Manage and collaborate with bioanalytical CROs to oversee method development, validation, and sample analysis for PK and biomarkers, ensuring high-quality and timely deliverables.

3. Regulatory & Documentation

• Medical Writing: Contribute to the drafting and review of Clinical Development Plans, Protocols, Clinical Study Reports (CSRs), Investigator Brochures (IBs), and product labeling regarding clinical pharmacology content.
• Submissions: Support regulatory submissions and prepare responses to queries from health authorities (e.g., NMPA, FDA, ICH) regarding DMPK and clinical pharmacology.

4. Leadership & Communication

• Cross-Functional Collaboration: Act as the primary Clinical Pharmacology representative, collaborating across multidisciplinary teams and with external consultants.
• Scientific Dissemination: Prepare manuscripts and conference posters; deliver training on clinical pharmacology topics internally and externally when required.

Qualifications:

1. Education: Master’s degree or above in Clinical Pharmacology, Quantitative Pharmacology, Pharmacokinetics, or a related discipline.
2. Experience:
   • At least 3 years of clinical pharmacology experience in the pharmaceutical industry, OR
   • 5+ years of combined experience in preclinical and clinical pharmacology roles.
3. Technical Expertise:
   • In-depth knowledge of PK/PD principles, quantitative pharmacology analyses, and clinical study concepts.
   • Proficiency in standard PK and modeling software (e.g., WinNonlin, NONMEM, R).
   • Familiarity with NMPA, FDA, and ICH regulatory guidelines.
4. Skills:
   • Strong communication and teamwork skills.
   • Language: Good English proficiency in listening, speaking, reading, and writing.

Job Location: Suzhou, Hefei

Position Overview

Ractigen Therapeutics is a clinical-stage biotechnology company pioneering the development of Small Activating RNA (saRNA) therapeutics. We are seeking highly motivated and talented scientists at all levels—from Senior Scientist to Director—to join our growing R&D team.

Successful candidates will play a pivotal role in advancing our RNA therapeutic pipeline. Depending on experience, you will serve as a Project Lead or Therapeutic Area Lead, driving programs from target evaluation and proposal through preclinical proof-of-concept (POC) to IND-enabling studies and regulatory filing.

Key Responsibilities

1. Project & Strategic Leadership (Scope varies by level)

• Scientist / Senior Scientist: Act as a key technical lead for specific projects; design and execute in vitro and in vivo studies to validate targets and screen RNA candidates.
• Associate Director: Serve as Project Lead; independently propose new drug discovery projects, design the critical path for PCC (Preclinical Candidate) selection, and manage cross-functional resources to meet timelines.
• Director: Serve as Therapeutic Area Lead; define the strategic roadmap for a specific disease area (e.g., CNS, Metabolic, Oncology); oversee the entire portfolio from concept to IND filing; manage and mentor a team of scientists.

2. Scientific Execution: Biology & Pharmacology

• Target Discovery: Conduct comprehensive literature reviews and bioinformatics analysis to identify and propose novel targets suitable for RNA therapeutics including saRNA and siRNA.
• Validation & Screening: Develop robust cellular assays (qPCR, Western Blot, ELISA, functional assays) to validate target engagement and screen oligonucleotide sequences.
• In Vivo Pharmacology: Design and oversee animal efficacy studies (mouse/rat/NHP); analyze PK/PD relationships to guide dose selection and optimization.

3. Preclinical Development & IND-Enabling

• Lead the transition of programs from discovery to development.
• Design and manage IND-enabling studies (GLP toxicology, safety pharmacology, biodistribution) in collaboration with internal teams and external CROs.
• Author and review pharmacology/biology sections of regulatory submissions (IND/CTA) to the NMPA, FDA, and other health authorities.

Qualifications

1. Education & Training (Required for All Levels)

• Ph.D. in Pharmacology, Biology, Biomedical Sciences, or a related discipline.
• Postdoctoral training in a reputable academic or industrial lab is highly preferred.

2. Experience Requirements

• Scientist / Senior Scientist: 0–4 years of post-PhD experience. Strong hands-on skills in molecular biology and animal handling.
• Associate Director: 5–8 years of industrial experience with a track record of leading projects from discovery to lead optimization.
• Director: 8+ years of industrial experience with proven success in advancing programs to IND filing. Experience managing teams is required.

3. Technical & Professional Skills

• Oligonucleotide Expertise: Prior experience in the discovery and development of RNA therapeutics (ASO, siRNA, saRNA, mRNA) is a strong plus.
• Drug Discovery Knowledge: Deep understanding of the drug discovery process, including assay development, in vivo pharmacology, and DMPK/Tox principles.
• Language: Excellent English communication skills (both spoken and written) are a MUST. Ability to write high-quality scientific reports and present complex data clearly.
• Soft Skills: Strong problem-solving abilities, adaptability, and a collaborative spirit in a fast-paced biotech environment.

How to Apply

Please submit your CV (in both English) and a Cover Letter indicating the level (Scientist/AD/Director) you are applying for to: hr@ractigen.com

Job Location: Suzhou

Report to: CTO

Position Overview:

Ractigen Therapeutics is a global leader in the development of Small Activating RNA (saRNA) therapeutics. We are seeking a highly motivated and experienced Director of Neuroscience to build and lead our CNS discovery pipeline.

The successful candidate will lead the biological strategy for treating neurodegenerative and neuromuscular diseases by exploiting Ractigen’s diverse oligonucleotide platforms. This role requires deep expertise in neurobiology and RNA therapeutics, with a mandate to develop interventions that modulate gene expression (via both upregulation and silencing mechanisms) to address complex CNS disease drivers.

Key Responsibilities:

1. CNS Pipeline Strategy & Leadership

• Define and execute the strategic roadmap for Ractigen’s neuroscience portfolio. Identify high-value targets where RNA-based modulation—whether restoring expression of a haploinsufficient gene or silencing a toxic gain-of-function mutation—offers a distinct therapeutic advantage.
• Lead a team of scientists to drive projects from Target Identification & Validation through Lead Optimization, to Candidate Selection (PCC) and IND filing.
• Serve as the primary biology lead for CNS programs, making data-driven Go/No-Go decisions based on molecular biology, pharmacology, and safety data.

2. Pharmacology & In Vivo Biology

• Design and oversee robust in vitro and in vivo proof-of-concept studies to demonstrate target engagement and the desired functional outcome and phenotypic rescue.
• Establish and validate relevant cellular (iPSC-derived neurons) and animal models for neurodegenerative diseases (e.g., ALS, Alzheimer’s, CNS genetic disorders).
• Delivery Validation: Collaborate closely with the Chemistry/Delivery team to evaluate novel CNS delivery systems, including conjugates (AOCs/ligands) for systemic delivery and formulations for intrathecal (IT) or intracerebroventricular (ICV) administration.

3. PK/PD & Translational Medicine

• Design studies to characterize the Pharmacokinetics (PK) and Pharmacodynamics (PD) of oligonucleotides in the CNS (brain tissue distribution, CSF dynamics, intracellular uptake).
• Develop translatable biomarkers to facilitate the transition from preclinical research to clinical development.

4. External Collaboration & Management

• Manage relationships with CROs for specialized neuro-behavioral studies, histology, and safety assessments.
• Represent Ractigen in scientific meetings and collaborations with academic or industry partners.

Qualifications:

1. Education: Ph.D. in Neuroscience, Neuropharmacology, or a related biological science.
2. Experience:
   • 6+ years of drug discovery experience in the biotech or pharmaceutical industry, with at least 2 years in a leadership role.
   • Essential: Direct experience with Nucleic Acid Therapeutics (siRNA, ASO, or saRNA) in the CNS context.
3. Technical Expertise:
   • Deep understanding of neuroanatomy and neurodegenerative disease mechanisms.
   • Proven track record in managing CNS delivery studies (e.g., IT/ICV dosing techniques, biodistribution analysis).
   • Experience with BBB penetrating technologies (e.g., receptor-mediated transport) is a significant plus.
4. Leadership: Strong ability to lead cross-functional teams and mentor junior scientists in a fast-paced, innovative environment.

Job Location: Suzhou

Report to: CEO

Position Overview:

Ractigen Therapeutics is a clinical-stage biotechnology company pioneering the development of saRNA (small activating RNA) therapeutics. We are seeking a visionary Vice President of Oligonucleotide Chemistry to architect the future of our chemical platform.

In this strategic leadership role, you will architect the roadmap for next-generation RNA chemistry. You will drive proprietary innovations in oligonucleotide modification to enhance the therapeutic index of our molecules. Crucially, you will pioneer our Targeted Delivery Platform, spearheading the development of Antibody-Oligonucleotide Conjugates (AOCs) and other ligand-directed technologies to overcome the barriers of extra-hepatic delivery and enable precision tumor targeting

Key Responsibilities:

1. Innovation in Nucleic Acid Chemistry

• Novel Modifications: Lead the design and synthesis of proprietary chemical modifications (sugar, base, and backbone chemistries) to enhance the potency, metabolic stability, and safety profile of saRNA, minimizing off-target effects and immunogenicity.
• Platform Evolution: Benchmark against industry standards (e.g., cEt, LNA, MOE, 2’-F/2’-OMe patterns) to develop a differentiated, best-in-class chemical platform.

2. Delivery Platform & Bioconjugation (Strategic Focus)

• AOC Strategy: Spearhead the development of AOCs. Design stable and cleavable linker chemistries to enable precise, cell-specific delivery of RNA payloads using antibodies or Fabs.
• Ligand-Drug Conjugates (LDC): Expand the delivery toolkit beyond GalNAc. Direct the design of novel ligands (lipids, peptides, small molecules) to target extra-hepatic tissues (e.g., CNS, muscle, adipose tissue, tumor).

3. R&D Strategy & Pipeline Leadership

• SAR/SPR Leadership: Oversee the establishment of robust Structure-Activity Relationships (SAR) and Structure-Property Relationships (SPR) to rapidly cycle from hit-to-lead to candidate selection.
• Scalability & CMC: Ensure that novel chemistries and conjugates are designed with scalability in mind. Collaborate with CMC teams to transition molecules from discovery scale (mg) to process development (g/kg).
• Cross-Functional Integration: Work closely with Biology, DMPK, and Toxicology VPs to align chemical innovation with biological performance and safety requirements.

4. Intellectual Property & External Collaboration

• IP Estate: Aggressively expand Ractigen’s intellectual property portfolio by patenting novel chemical entities, linkers, and conjugation platforms.
• Partnerships: Evaluate and manage high-level collaborations with CDMOs, academic partners, or biotech partners for licensing novel delivery technologies.

Qualifications:

1. PhD in a biological or pharmaceutical-related field with over 8 years of business development experience in the biotech or pharmaceutical industry, including a proven track record of successful in-licensing/out-licensing deals.
2. Experience in developing and executing business development strategies that contribute to company growth.
3. Strong scientific acumen, analytical mindset, and deep familiarity with the drug discovery and development process.
4. Proven ability to craft compelling business narratives and develop high-impact BD materials that resonate with stakeholders.
5. Self-driven with strong problem-solving, collaboration skills, and a keen ability to identify and capitalize on business opportunities.
6. Excellent organizational and time management skills, with the ability to interact effectively with potential partners, internal teams, and senior management.
7. Exceptional English communication and presentation skills, with the ability to influence internal and external stakeholders.